TABLE 4. Model discrimination analysis for 4MP and IND binding to CYP2E1.
Tested models are shown in Scheme 3. The asterisk denotes complexes contributing to the observed signal. P indicates the number of adjustable parameters for the model; RSS indicates the relative sum of the squares; ΔAICc shows the increase in the second-order Akaike information criterion relative to the best model (ΔAICc 0); w indicates the Akaike weight such that 0.10 = 10% probability. Minimal sum of squares for 4MP studies was 0.0000015 and the value for IND studies was 0.00000123.
| Model | P | 4MP
|
IND
|
||||
|---|---|---|---|---|---|---|---|
| RSS | ΔAICc | w | RSS | ΔAICc | w | ||
| EL* | 3 | 1.595 | 27.4 | 0.000 | 1.000 | 0.0 | 0.725 |
| EL*, EL2 | 4 | 1.367 | 19.5 | 0.000 | 1.000 | 2.4 | 0.218 |
| EL, EL2* | 4 | 1.749 | 36.7 | 0.000 | 5.219 | 99.9 | 0.000 |
| EL*, EL2* | 5 | 1.000 | 0.0 | 1.000 | 1.003 | 5.1 | 0.057 |