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. Author manuscript; available in PMC: 2014 Feb 24.
Published in final edited form as: Circulation. 2013 May 30;128(1):60–71. doi: 10.1161/CIRCULATIONAHA.113.001533

Figure 1. Increased hind limb autoamputation in both male and female ARKO mice after femoral arteriectomy.

Figure 1

(A) Representative photographs of hind limbs of male WT and male ARKO mice at day 21 after ischemic surgery. (B) Limb survival rate after ischemic surgery in male WT and ARKO mice. Autoamputation of the hind limb was defined as extended necrosis above the knee. n=17 in each male mice group. **P<0.01, male ARWT vs. male ARKO using Log-rank test. (C) Limb survival rate after ischemic surgery in female WT and ARKO mice. n=25 in the female WT mouse group and n=12 in the female ARKO mouse group. **P<0.01, female ARWT vs. female ARKO using Log-rank test.