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. Author manuscript; available in PMC: 2014 Feb 24.
Published in final edited form as: Circulation. 2013 May 30;128(1):60–71. doi: 10.1161/CIRCULATIONAHA.113.001533

Figure 8. Schematic diagram of associations between AR and VEGF receptor signaling pathways.

Figure 8

VEGF rapidly induces KDR dimerization and autophosphorylation, followed by the recruitment and activation of Src and PI3K. On the other hand, AR activates the Akt/eNOS cascade depending on association with PI3K and Src. Thus, association between AR and KDR promotes cell survival and angiogenesis via recruitment of Src and PI3K.