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. 2014 Feb 5;13:22. doi: 10.1186/1476-4598-13-22

Table 1.

SAP-dependent Mkl1 target genes

Gene Description Fold Reduction in HC11-∆SAP vs. HC11-FL cells
 Functions
Microarrays in 0.03% FCS qRT-PCR in 0.03% FCS qRT-PCR in 3% FCS
SRF-independent genes
Tnc
 Tenascin C, ECM protein
 3.07***
 3.50***
 26.34***
 Cell adhesion, cell migration, wound healing and tissue remodeling, cancer cell invasion and metastasis [10]
Anln
 Anillin, actin binding protein
 3.10***
 1.93***
 1.38**
 Cell cycle regulation [26], cell motility and cancer progression [26-28]
Nox4
 NADPH oxidase 4
 3.31***
 94.19**
 332.70***
 Cell growth, differentiation and migration [29], tumor angiogenesis [30]
Adamts16
 Metallopeptidase, ECM protein
 3.63***
 5.70***
 14.84**
 Cell growth and motility [31], role in arthritis [32] and cancer [31]
Krt5
 Keratin 5, intermediate filament protein
 3.73***
 2.74***
 8.02***
 Protein synthesis, epithelial cell growth and differentiation [33,34]
p15 (PAF)
 2810417H13Rik, PCNA-associated factor
 3.91***
 1.89***
 1.34***
 DNA repair and cell cycle regulation, cell survival and proliferation, tumorigenesis [35-37], hematopoiesis [38]
Ass1
 Argininosuccinate synthetase 1
 4.23***
 3.89**
 2.72**
 Regulation of nitric oxide production and cell viability [39,40]
Cd34
 CD34 antigen, stem cell antigen
 4.25***
 10.61***
 1.72***
 Vessel development and function [41], tumor growth [42,43]
Wisp1
 WNT1 inducible signaling pathway protein 1, ECM protein
 4.41***
 2.54**
 4.06**
 Cell proliferation and survival, ECM deposition and turnover, EMT, tumorigenesis, tissue remodeling [44]
Mcm6
 Minichromosome maintenance complex component 6
 4.42***
 2.83***
 1.30***
 Cell cycle regulation [45]
Car12
 Carbonic anyhydrase 12
 4.58***
 16.11***
 26.07**
 Cell survival under hypoxic conditions, tumor-associated cell migration and invasion [46,47]
Htatip2
 Hyaluronectin, TIP30, transcriptional regulator
 5.89***
 548.59***
 245.27***
 Regulation of apoptosis [48], tumor growth and metastasis [49]
Kif26b
 Kinesin family member 26B
 6.33***
 8.36***
 61.22***
 Regulation of adhesion and cell polarity in kidney development [50]
SRF-dependent genes
Lox
 Lysyl oxidase, ECM protein
 4.61***
 4.70**
 12.04***
 ECM turnover, connective tissue remodeling and repair, tumor progression and metastasis [51,52]
Mmp12
 Matrix metallopeptidase 12, metalloelastase
 12.01***
 23.49***
 4.90**
 ECM degradation in tissue remodeling [49] and tumorigenesis [53]
Mmp3 Matrix metallopeptidase 3, stromelysin-1 15.64*** 14.70*** 2.08** ECM degradation in tissue remodeling [49] and tumorigenesis [54]

Abbreviations: ECM extracellular matrix protein, PCNA proliferating cell nuclear antigen, EMT epithelial-to-mesenchymal transition.

***P < 0.001, **P < 0.01, Student’s t test.