Figure 2. Effects of exposure to 250ng BPA/kg/day on mice exposed from E8 to E18.
Carmine –stained whole mounts of E18 4th mammary gland of controls (A), and BPA exposed embryos (B). Note the increased size of the epithelial cords, compared with controls. Lumen formation in E18 mouse mammary glands is inhibited by BPA treatment. Lumen formation [arrow] was observed in 38% of control animals (C) but in none of the histological sections of animals exposed in utero to 250ng BPA/kg BW/day from E9(D). Scale bars represent 100μm. Copyright 2007, The Endocrine Society, reprinted with permission [55]