. Author manuscript; available in PMC: 2014 Dec 12.

Published in final edited form as: J Med Chem. 2013 Nov 23;56(23):9756–9770. doi: 10.1021/jm401468w

Table 1.

Antibacterial Activity of Benzimidazoles 5 Against Mtb H37Rv Strain (MIC, µg/mL) and Their Cytotoxicity (IC₅₀, µg/mL)

Compound	MtbH37Rv MIC	Vero Cytotoxicity
1	0.63	>100
5a	6.25	>100
5b	>100	>100
5c	100	>100
5d	>100	>100
5e	50.0	>50
5f	0.06	>100
5g	>50	>100
5h	0.16	>100
5i	3.13	>100
5j	1.56	>100
5k	1.56	>100
51	0.31	>100
5m	12.5	>100
5n	1.56	>100
5o	0.31	>100
5p	0.63	>100