Table 3.
Antibacterial Activity of Benzimidazoles 7 Against Mtb H37Rv Strain (MIC, µg/mL) and Their Cytotoxicity (IC50, µg/mL)
| Compound | R1R2N | R3 | Mtb H37Rv | Vero Cytotoxicity |
Compound | R1R2N | R3 |
Mtb H37Rv MIC |
Vero Cytotoxicity |
|---|---|---|---|---|---|---|---|---|---|
| 7a-1 |  |
 |
>100 | >100 | 7b-6 |  |
 |
6.25 | >100 |
| 7a-2 |  |
 |
>100 | >100 | 7b-7 |  |
 |
12.5 | >100 |
| 7a-3 |  |
 |
>100 | >100 | 7c-1 |  |
 |
1.56 | >100 |
| 7a-4 |  |
 |
12.5 | >100 | 7c-2 |  |
 |
0.31 | >100 |
| 7a-5 |  |
 |
1.56 | >100 | 7c-3 |  |
 |
0.31 | >100 |
| 7a-6 |  |
 |
>100 | n.d* | 7c-4 |  |
 |
0.16 | >100 |
| 7a-7 |  |
 |
12.5 | n.d* | 7c-5 |  |
 |
0.31 | >100 |
| 7a-8 |  |
 |
10.0 | >100 | 7c-6 |  |
 |
0.16 | >100 |
| 7a-9 |  |
 |
100 | >100 | 7c-7 |  |
 |
0.63 | >100 |
| 7a-10 |  |
 |
>100 | >100 | 7c-8 |  |
 |
1.56 | >100 |
| 7a-11 |  |
 |
>100 | >100 | 7c-9 |  |
 |
5.0 | >100 |
| 7a-12 |  |
 |
>100 | >100 | 7c-10 |  |
 |
6.25 | >100 |
| 7a-13 |  |
 |
25.0 | >100 | 7c-11 |  |
 |
0.31 | >100 |
| 7a-14 |  |
 |
12.5 | n.d* | 7c-12 |  |
 |
3.13 | >100 |
| 7a-15 |  |
 |
25.0 | >100 | 7c-13 |  |
 |
0.63 | >100 |
| 7b-1 |  |
 |
6.25 | >100 | 7c-14 |  |
 |
0.31 | >100 |
| 7b-2 |  |
 |
6.25 | >100 | 7c-15 |  |
 |
1.25 | >100 |
| 7b-3 |  |
 |
3.13 | >100 | 7c-16 |  |
 |
6.25 | <50 |
| 7b-4 |  |
 |
1.56 | >100 | 7c-17 |  |
 |
>100 | >100 |
| 7b-5 |  |
 |
12.5 | >100 | 7d |  |
 |
>100 | >100 |
*
nd. = not determined