Table 3. AGXT2 SNPs and biochemical measures.
| AGXT2 rs37369 | AGXT2 rs16899974 | ||||||||
| WT (c.418 GG) | Hetero (c.418 GA) | Homo (c.418 AA) | p value | WT (c.1492 GG) | Hetero (c.1492 GT) | Homo (c.1492 TT) | p value | ||
| Plasma (µmol/L) * | n = 345 | n = 46 | n = 4 | n = 239 | n = 139 | n = 17 | |||
| SDMA | 0.41 (0.37–0.44) | 0.43 (0.39–0.47) | 0.49 (0.46–0.56) | 0.002 | 0.41 (0.37–0.44) | 0.42 (0.38–0.46) | 0.40 (0.37–0.45) | n.s. | |
| BAIB | 0.98 (0.79–1.22) | 1.51 (1.22–1.95) | 2.41 (1.80–2.72) | <0.001 | 0.94 (0.74–1.21) | 1.12 (0.88–1.38) | 1.38 (0.96–1.89) | <0.001 | |
| ADMA | 0.37 (0.34–0.42) | 0.38 (0.34–0.42) | 0.36 (0.34–0.43) | n.s. | 0.37 (0.34–0.41) | 0.38 (0.34–0.42) | 0.37 (0.34–0.42) | n.s. | |
| L-arginine | 72.7 (57.4–96.4) | 80.1 (61.2–116.3) | 94.0 (70.0–146.8) | n.s. | 74.3 (56.5–98.5) | 71.5 (60.2–95.4) | 82.8 (66.7–107.5) | n.s | |
| Urine (µmol/g creatinine) | n = 347 | n = 49 | n = 4 | n = 239 | n = 143 | n = 18 | |||
| SDMA | 35.9 (31.6–42.0) | 37.3 (32.7–43.4) | 33.4 (26.8–37.4) | n.s. | 35.7 (32.1–41.1) | 37.3 (31.0–42.7) | 33.4 (30.9–44.0) | n.s. | |
| BAIB | 49.4 (31.6–75.3) | 165 (83.5–280) | 863 (404–1246) | <0.001 | 47.0 (28.3–75.3) | 65.5 (42.4–105) | 125 (57.8–263) | <0.001 | |
| ADMA | 32.1 (27.1–38.1) | 30.4 (27.2–37.1) | 25.5 (20.9–27.8) | n.s. | 31.6 (27.2–37.2) | 32.2 (26.4–38.6) | 29.9 (26.6–39.7) | n.s. | |
| L-arginine | 14.0 (10.8–18.7) | 13.6 (10.7–19.0) | 12.4 (10.2–13.0) | n.s. | 14.0 (10.7–19.0) | 13.8 (11.0–17.4) | 14.3 (10.7–30.3) | n.s. | |
| Creatinine | |||||||||
| Serum (mg/dL) † | 0.8 (0.7–0.9) | 0.8 (0.7–0.9) | 1.0 (0.9–1.0) | <0.05 | 0.8 (0.7–0.9) | 0.8 (0.7–0.9) | 0.8 (0.7–0.9) | n.s. | |
| Urine (mg/dL) | 86 (37–146) | 71 (37–134) | 144 (99–169) | n.s. | 80 (34–147) | 89 (38–139) | 117 (38–185) | n.s. | |
| Clearance (ml/min) † ‡ | 123 (109–142) | 125 (102–144) | 120 (109–127) | n.s. | 123 (109–141) | 123 (109–144) | 112 (102–140) | n.s. | |
Median values (25–75% percentile) are shown. The Kruskal-Wallis test was used for statistical analysis.
* Plasma concentrations of methylarginines, BAIB and L-arginine were determined for 395 volunteers.
†
Serum concentrations of creatinine were determined for 390 volunteers.
‡
Cockgroft-Gault formula was used for calculation of creatinine clearance.
ADMA, asymmetric dimethylarginine; AGXT2, alanine-glyoxylate aminotransferase 2; BAIB, β-aminoisobutyrate; Hetero, heterozygous for minor allele; Homo, homozygous for minor allele; SDMA, symmetric dimethylarginine; WT (wild-type), homozygous for major allele.