Table 2.

Description of medication, technology-based intervention, and the medication adherence measure of randomized controlled trials included in the review

Study	Medication	Intervention	Adherence
Boker et al, 20124	• Topical medication (12 weeks)  – Morning: OTC facial cleanser, followed by 3 pea-sized amounts of clindamycin/benzoyl peroxide 1%/5% topical gel  – E vening: 1 pea-sized amount adapalene 0.3% gel	• Type: text message reminder • Frequency: twice a day • Duration: 12 weeks	• Measurement: MEMS cap • Calculation: actual number of correct MEMS cap opening/closing events for each tube divided by the expected number of opening/closing events
Yentzer et al, 20115	• Topical medication (12 weeks): adapalene 0.1% gel once-daily	• Type: telephone call reminder • Frequency: once a day • Duration: 12 weeks	• Measurement: MEMS cap • Calculation: not specified
Yentzer et al, 20116	• Topical medication (12 weeks): benzoyl peroxide 5% gel once-daily	• Type: Internet-based communication: email containing a link to a survey assessing acne severity and treatment • Frequency: once a week • Duration: 12 weeks	• Measurement: MEMS cap; patients’ report • Calculation: percentage of days the medication container was opened
Wang et al, 20117	• Not specified	• Type: Internet-based interactive health care education tool • Frequency: once a week • Duration: 12 weeks	• Measurement: clinical outcomes and quality of life

Abbreviations: OTC, over-the-counter; MEMS, Medication Event Monitoring System.