Table 1.
France
|
Spain
|
UK
|
||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
All patients (n=1,374) |
Biologic treatment (n=125) |
Nonbiologic treatment (n=1,249) |
P-valueb | All patients (n=561) |
Biologic treatment (n=109) |
Nonbiologic treatment (n=452) |
P-valueb | All patients (n=574) |
Biologic treatment (n=48) |
Nonbiologic treatment (n=526) |
P-valueb | |
Mean age, years | 46.6 | 50.4 | 46.3 | 0.0005 | 42.4 | 42.8 | 42.3 | 0.77 | 43.9 | 44.3 | 43.8 | 0.82 |
Male | 769 (56.0%) | 78 (62.4%) | 691 (55.3%) | 0.13 | 329 (58.7%) | 71 (65.1%) | 258 (57.1%) | 0.12 | 301 (52.4%) | 25 (52.1%) | 276 (52.5%) | 0.96 |
Mean length of diagnosis, years | 9.2 | 15.0 | 8.6 | <0.0001 | 9.5 | 11.8 | 8.8 | 0.0186 | 12.4 | 14.8 | 12.2 | 0.16 |
BMI ≥30c | 135 (9.8%) | 26 (21.0%) | 109 (8.7%) | <0.0001 | 52 (9.3%) | 18 (16.5%) | 34 (7.6%) | 0.003 | 86 (15.0%) | 14 (29.2%) | 72 (13.7%) | 0.2 |
Mean PASI scored | 9.9 | 14.7 | 9.4 | <0.0001 | 9.6 | 12.9 | 8.6 | 0.0005 | 10.4 | 13.0 | 10.2 | 0.10 |
Nail involvement | 355 (25.8%) | 60 (48.0%) | 295 (23.6%) | <0.000l | 165 (29.4%) | 53 (48.6%) | 112(24.8%) | <0.0001 | 244 (42.5%) | 24 (50.0%) | 220 (41.8%) | 0.27 |
Psoriatic arthritise | 127(9.2%) | 44 (35.2%) | 83 (6.6%) | <0.000l | 35 (6.2%) | 17 (15.6%) | 18 (3.9%) | <0.0001 | 75 (13.0%) | 22 (45.8%) | 53 (10.0%) | <0.000l |
Notes:
A total of 79 patients were excluded from 2,588 patients; all values are percentages unless otherwise indicated;
P-values are for the comparison between biologic users and nonusers in each country;
BMI data were available for only 1,369 patients from France, 557 patients from Spain, and 360 patients from the UK;
mean PASI scores were calculated from measured or imputed data for 1,270, 481, and 538 patients from France, Spain, and the UK, respectively;
psoriatic arthritis was reported for only 1,374 patients from France, 546 patients from Spain, and 570 patients from the UK.
Abbreviations: BMI, body mass index; CI, confidence interval; PASI, Psoriasis Area and Severity Index.