Table 3.
Gene expession associated with patient outcomes
| Control set | P-value* | Bev qPCR Set | P-value* | |
|---|---|---|---|---|
|
ORR |
|
|
|
|
|
ALDH6A1 + TFF2 + MCM5
|
|
|
|
|
| All low |
4/11 (36.4%) |
0.747 |
6/7 (85.7%) |
0.007 |
| Other |
27/61 (44.3%) |
|
12/42 (28.6%) |
|
|
Odds ratio for response |
|
|
|
|
|
ALDH6A1 + TFF2 + MCM5
|
|
|
|
|
| All low vs. any other |
0.72 |
0.6273 |
15.00 |
0.0168 |
|
Hazard ratio for progression |
|
|
|
|
|
KLF12 + TFF2
|
|
|
|
|
| Other vs. (KLF12 high + TFF2 low) |
1.29 |
0.39 |
2.92 |
0.03 |
|
ALDH6A1 + TFF2
|
|
|
|
|
| Other vs. All low | 1.76 | 0.0404 | 0.89 | 0.7406 |
*Critical point for the significance of p-values is a = 0.05/(N of comparisons) = 0.05/27 = 0.001852 (Bonferroni correction).