Table 3.

Association of baseline plasma vitamin E level and incident whole knee radiographic OA (WK ROA) in subjects with no ROA at baseline: A. Women and B. Men

	A. Incident WK ROA-Women only (n=336 knees, 168 ppts/50 events)			B. Incident WK ROA-Men only (n=238 knees, 119 ppts/30 events)
Baseline vitamin E level	Incident Knee Events/Observations (%)	Model 2: Adjusted OR (95%CI); P-value	Model 3: Adjusted OR (95%CI); P-value	Incident Knee Events/Observations (%)	Model 2: Adjusted OR (95%CI); P-value	Model 3: Adjusted OR (95%CI); P-value
The Lowest Tertile	10 / 112 (8.9%)	Reference 1.0	Reference 1.0	13 / 86 (15.1%)	Reference 1.0	Reference 1.0
Middle Tertile	16 / 96 (16.7%)	2.86 (1.09-7.52) 0.033	2.72 (1.04-7.09) 0.041	5 / 68 (7.4%)	0.48 (0.17-1.34) 0.160	0.49 (0.17-1.39) 0.177
The Highest Tertile	24 / 128 (18.8%)	3.43 (1.36-8.66) 0.009	3.07 (1.24-7.60) 0.016	12 / 84 (14.3%)	0.99 (0.41-2.41) 0.990	0.85 (0.35-2.10) 0.729
Test for trend		0.014	0.026		0.786	0.934

Model 2 - Adjusted for age, nonwhite race, clinic site, and BMI

Model 3 - Adjusted for age, nonwhite race, clinic site, BMI and vitamin E tertiles and vitamin C tertiles.