TABLE IV.
Mineral composition of femora from male and female PAI-1.stab and WT mice at 16 and 32 weeks of age (n=8–11), mean + SD.
| Parameters | Males | Females | ||||||
|---|---|---|---|---|---|---|---|---|
| 16 weeks | 32 weeks | 16 weeks | 32 weeks | |||||
| WT | PAI-1. stab | WT | PAI-1. stab | WT | PAI-1. stab | WT | PAI-1. stab | |
| F (ppm) | 673.3±38.4 | 350.9a±31.3 | 1119.0b±95.7 | 630.3ab±54.0 | 629.6±48.0 | 332.0a±58.7 | 1422.0bc±61.9 | 513.0abc±48.9 |
| Mg (ppm) | 5239±156 | 5056±191 | 4653±207 | 4613±183 | 5672±763 | 4662a±274 | 4939±717 | 4927±1353 |
| K (ppm) | 158.6±63.0 | 233.8±114.0 | 152.0±62.2 | 185.1±63.4 | 122.9±50.6 | 262.2a±160.6 | 160.9±63.2 | 202.7±58.4 |
| Cl (ppm) | 74.53±24.42 | 93.84±50.15 | 72.70±24.33 | 136.50a±26.78 | 76.97±26.03 | 78.97±40.70 | 54.62±21.56 | 71.68c±28.17 |
| Zn (ppm) | 226.3±58.7 | 177.3±39.1 | 224.1±50.4 | 154.9±39.3 | 227.8±72.6 | 213.1±59.1 | 285.4±83.7 | 259.7c±76.9 |
| Na (ppm) | 4080±190 | 4093±204 | 4287±133 | 4651±165 | 4399±637 | 4199±246 | 3997±613 | 4691±1555 |
| Ca (ppm) | 251328±3380 | 244329±7742 | 247766±5223 | 258828±3629 | 264032±35345 | 236207±12023 | 232935±33744 | 257048±75666 |
| P (ppm) | 117328±1358 | 115085±3345 | 116700±2410 | 120008±2582 | 127384±16864 | 114662±5031 | 117673±2589 | 129449±30217 |
| Ca/P | 2.14±0.03 | 2.12±0.04 | 2.12±0.04 | 2.16±0.03 | 2.07c±0.03 | 2.06c±0.03 | 2.06c±0.04 | 2.10±0.06 |
a
Indicates significant genotype-dependent difference; WT vs PAI-1 for same gender and age; p<0.05
b
Indicates significant age-dependent difference; 16 weeks vs 32 weeks for same gender and genotype; p<0.05
c
Indicates significant gender-dependent difference; male vs female for same age and genotype; p<0.05