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The secondary structure and titration curve of the binding of metal complexes to the apo-form of the BRCA1 protein (without Zn2+). (A) The effect of the ruthenium(II) complexes on the secondary structures of proteins was predicted by the CONTIN program. The relative secondary structure of the Ru-BRCA1 adducts at 50 μM of the complexes were plotted. (B) Changes in the ellipticity of the protein at 208 nm with increasing metal concentrations were plotted.
