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. 2013 Dec 10;8:201. doi: 10.1186/1746-1596-8-201

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Copyright © 2013 Shilo et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cytoplasmic (a-e) and nuclear (a, c and e) expression of PRMT5 is seen throughout the entire spectrum of lung tumors; representative examples of adenocarcinoma (a), squamous cell carcinoma (b-c), large cell neuroendocrine carcinoma (d) and typical carcinoid tumor (e); no PRMT5 is observed in normal alveolar parenchyma (f) Panels (b) and (d) illustrate low and high cytoplasmic expression, respectively; panels (a) and (e) illustrate low and high nuclear expression, respectively; immunohistochemistry; original magnification ×400.