Table 2.
PRMT5 expression in NSCLC
| Cytoplasmic high PRMT5, n (%) | P | Nuclear high PRMT5, n (%) | P | N a | ||
|---|---|---|---|---|---|---|
| Age |
≤60 years (n = 65) |
11 (5.4) |
0.36 |
22 (10.8) |
0.55 |
204 |
| >60 years (n = 139) |
30 (14.7) |
55 (27.0) |
||||
| Gender |
Female (n = 53) |
9 (4.1) |
0.79 |
19 (8.8) |
0.25 |
217 |
| Male (n = 164) |
35 (16.1) |
62 (28.6) |
||||
| Size |
≤3 cm (n = 74) |
9 (6.3) |
0.09 |
31 (21.8) |
0.35 |
142 |
| >3 cm (n = 68) |
18 (12.7) |
22 (15.5) |
||||
| Stage |
I (n = 81) |
14 (9.9) |
0.63 |
32 (22.7) |
0.19 |
141 |
| II-IV (n = 60) |
13 (9.2) |
21 (14.9) |
||||
| Grade |
WD, MD (n = 55) |
7 (7.2) |
0.01 |
20 (20.6) |
0.98 |
97 |
| PD (n = 42) |
16 (16.5) |
16 (16.5) |
||||
| Histology |
ADC (n = 113) |
19 (8.3) |
0.04 |
28 (12.2) |
<0.001 |
229 |
| SQC (n = 116) |
28 (12.2) |
59 (25.8) |
||||
| Survival |
Yes (n = 44) |
9 (4.8) |
0.37 |
14 (7.4) |
0.54 |
189 |
| No (n = 145) | 30 (15.9) | 57 (30.2) |
Abbreviations: Neg negative, N number of cases, WD well differentiated, MD moderately differentiated, PD poorly differentiated, ADC adenocarcinoma, SQC squamous cell carcinoma.
a Reflects total number of cases with available annotations.