Table 3.
APC mutations in Iranian sporadic CRC patients; novel mutations are in bold.
| Patient ID | DNA change | Protein change | Mutation type | Origin |
|---|---|---|---|---|
| 3 & 7 | c.3527C>T | p.Pro1176Leu | Missense | Somatic |
| 7 | c.2804dupA | p.Tyr935fsX1 | Frameshift | Somatic |
| 18 | c.3236C>G | p.Thr1079Ser | Missense | Germline |
| 18 | c.4099C>T | p.Gln1367X | Nonsense | Somatic |
| 20 | c.4317delT | p.Pro1440HisfsX33 | Frameshift | Somatic |
| 23 & 30 | c.4348C>T | p.Arg1450X | Nonsense | Somatic |
| 25 | c.4464_4471delATTACATT | p.Leu1488PhefsX23 | Frameshift | Somatic |
| 28 | c.4468_4469dupCA | p.Phe1491IlefsX17 | Frameshift | Somatic |