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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Dev Neurobiol. 2013 Oct 7;74(3):218–232. doi: 10.1002/dneu.22123

Figure 2. Schematic of mechanisms regulating axonal mRNA populations.

Figure 2

Hypothetical ‘basal’ and ‘stimulated’ conditions are noted for inducible vs. constitutively expressed RNA binding proteins (RBPi and RBPc, respectively). A, For RBPi, an increase in the levels or activity of this RBPs with stimulation results in a redistribution of target mRNAs from cell body restricted or predominant to axonal predominant. B, For RBPc, a shift in mRNA levels upon stimulation allows the green mRNA to outcompete the red mRNA for axonal localization. This both increases axonal levels of the green mRNA and decreases axonal levels of the red mRNA.