Figure 2. Placental ABCA1-CpG5 and -CpG6 DNA methylation levels according to maternal and newborn metabolic profile. Higher maternal HDL-C levels at first trimester of pregnancy (A and B) and lower maternal glucose concentrations 2 h post-OGTT (C) were both associated with lower ABCA1 DNA methylation levels in the maternal side of the placenta. Panel D shows the negative correlation between ABCA1-CpG5 DNA methylation levels in the fetal side of placenta and cord blood triglyceride levels. ^aIncluded age, BMI, TG at first trimester and history of gestational diabetes as covariates. ^bAdjusted for gestational age and newborn sex. ^cCorrelation coefficient and P value obtained after log10-transformation of the cord blood triglyceride levels.