Figure 3. DNA methylation levels at ABCA1-CpG6 on the maternal side of the placenta according to glucose tolerance status and HDL-C levels. Women with impaired glucose tolerance (IGT) and low HDL-C levels (<1.44 mmol/L) had the highest ABCA1-CpG6 DNA methylation levels. Maternal glucose status and HDL-C levels interact to increase ABCA1 DNA methylation on maternal side of placenta (P = 0.04). ^aP values obtained in the Bonferroni post-hoc analysis by comparing low (<1.44 mmol/L) and medium (1.44–1.67 mmol/L) levels of HDL-C to levels >1.67 mmol/L in IGT group. ^bP value obtained in the Bonferroni post-hoc analysis by comparing HDL-C levels <1.44 mmol/L to levels >1.67 mmol/L in the entire cohort (n = 100).^cANCOVA adjusted for age and BMI at first trimester and history of GDM.