Table 2. Hierarchical linear regression predicting newborn neurobehavior at birth.

Predictors	β step 1	β step 2	R2	F
Outcome: Self-regulation
Infant sex	0.07	0.05
Maternal age	−0.04	−0.06
Birth weight	0.05	0.06
Maternal anxiety	0.15	0.14
Maternal depression	<0.001	0.05
NR3C1 CpG2 methylation	0.04	0.04
			0.03	0.95
Maternal depression x NR3C1 CpG2 methylation	-	−0.16*
		∆R2 = 0.02*	0.06	10.46

Outcome: Hypotonia
Infant sex	0.08	0.11
Maternal age	−0.10	−0.06
Birth weight	−0.36‡	−0.37‡
Maternal anxiety	−0.04	−0.02
Maternal depression	0.12	0.04
NR3C1 CpG2 methylation	0.03	0.03
			0.16	50.55‡
Maternal depression x NR3C1 CpG2 methylation	—	0.25‡
		∆R2 = 0.06‡	0.21	60.81‡

Outcome: Lethargy
Infant sex	0.14	0.16*
Maternal age	−0.03	0.002
Birth weight	−0.13	−0.14
Maternal anxiety	−0.05	−0.03
Maternal depression	0.19*	0.13
NR3C1 CpG2 methylation	−0.09	−0.09
			0.06	20.04
Maternal depression x NR3C1 CpG2 methylation	–	0.19†
		∆R2 = 0.03†	0.10	20.68†

Outcome: Hypotonia
Infant sex	0.08	0.09
Maternal age	−0.06	−0.05
Birth weight	−0.27‡	−0.27‡
Maternal tobacco use during pregnancy	0.13*	0.13*
Maternal anxiety	−0.05	−0.08
Maternal depression	0.15†	0.16†
11β-HSD-2 CpG4 methylation	0.06	0.06
			0.10	50.76‡
Maternal anxiety x 11β-HSD-2 CpG4 methylation	—	0.10*
		∆R2 = 0.01*	0.11	30.68*

^*P < 0.05, ^†P < 0.01, ^‡P < 0.001