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. 2014 Feb 21;7:77. doi: 10.1186/1756-3305-7-77

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Copyright © 2014 Sprong et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The ANTIDotE approach.Identification: Using state of the art proteomic and transcriptomic approaches we will identify novel tick salivary gland proteins. Characterization: These novel tick salivary gland proteins will be characterized using in silico, in vitro and in vivo techniques. Proof of concept: Promising candidates will be assessed in a proof of concept study as anti-tick vaccines to protect against tick-borne diseases. Both transmission as well as tick feeding parameters will be assessed. The symbols (from left to right) represent Babesia, Borrelia nd TBEV, respectively. Valorization plans: Through an integrated and multidisciplinary approach involving European public health institutes, health organizations and industrial companies, we will examine how to develop anti-tick vaccines and implement these in public health systems in Europe.