Figure 1.
Postinjury administration of 30 mg/kg/day of VPA for 7 days reduces contusion volume. Representative photographs of the brains of a vehicle- and VPA-treated animal. Animals were killed 7 days after injury. Quantification of the volume of cortical contusion revealed that VPA significantly reduced brain contusion volume (mean: 23.96 versus 14.19 mm3). Rostral-caudal extent of the damage detected in the injured cortex from the vehicle- and VPA-treated animals. (Data are presented as the mean ± SEM, significant difference by 1-way ANOVA. *P = .010, n = 5 per group.)