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Comparison of predicted (lines; median, 5–95th percentiles) vs. individual observed (symbols) plasma concentrations in six representative pediatric patients from adolescents (a) to neonates (f), after various dosing of oral sotalol. Predictions were made using software 1 (Simcyp®, left, filled circles) and 2 (PK-SIM®, right, empty circles). Observed data are taken from Refs. (37)
