Table III.
SNPs with Significant Effects on Indapamide Metabolism
| Parameter genotype | Number | C max (ng/mL) | T max (h) | Half-life (h) | AUCt (h ng mL−1) | AUCinf (h ng mL−1) | CLss/F (mL/h) |
|---|---|---|---|---|---|---|---|
| CYP2C9:rs4918758 | |||||||
| TT | 10 | 54.5 ± 13.3 a | 6.3 ± 4.0 a | 29.0 ± 10.9 a | 1,020 ± 200 a | 2,480 ± 950 a | 1,530 ± 310 a |
| CT | 12 | 68.4 ± 14.2 b | 5.5 ± 2.7 a | 33.0 ± 14.3 a | 1,330 ± 240 b | 3,550 ± 1,020 b | 1,170 ± 200 b |
| CC | 2 | 89.4 ± 15.6 c | 6.0 ± 2.8 a | 29.4 ± 6.7 a | 1,790 ± 290 c | 4,450 ± 1,290 b | 850 ± 140 c |
| P value | 0.007 | 0.935 | 0.757 | 0.000* | 0.036 | 0.001* | |
| CYP2C19:rs4244285 | |||||||
| GG | 9 | 56.3 ± 12.6 a | 5.8 ± 4.0 a | 28.2 ± 10.9 a | 1,050 ± 190 a | 2,500 ± 1,010 a | 1,480 ± 280 a |
| AG | 14 | 69.6 ± 18.0 b | 6.0 ± 2.8 a | 33.4 ± 12.5 a | 1,360 ± 330 b | 3,670 ± 1,070 a | 1,180 ± 320 b |
| P value | 0.049 | 0.630 | 0.144 | 0.009 | 0.016 | 0.013 | |
Data are mean ± SD; statistical significance was compared with the wild type using one-way ANOVA or independent-samples t test, except a Wilcoxon signed rank test was used for T max. LSD post hoc test was used for multiple comparisons of the CYP2C9 rs4918758 genotypes. Means with different characters differ significantly (p < 0.05). p values are those of one-way ANOVA or independent-samples t tests with Bonferroni adjustment for comparison among genotype groups on each parameter
*p < 0.0018