Table 1.
miRNA target sites are detectable in heat shock gene transcripts
| Gene name | Alt. name(s) | 3'UTR sizea | miRNA target search algorithm | miRNA target site search resultsb | Predicted regulatory miRNAsc |
|---|---|---|---|---|---|
| HSF1 | HSTF1 | 387 nt | TargetScan | 72 | miR-3714; miR-445-3p; miR-4666-3p; miR-4668-3p; miR-548c-3p; etc. |
| miRanda | 1 | miR-431 | |||
| DIANA-MicroT-CDS | 10 | miR-654-5p; miR-541-3p; miR-615-5p; miR-3619-5p; miR-92a-2-5p; etc. | |||
| RegRNA | 84 | miR-1205; miR-1226; miR-3934; miR-1825; miR-1972; etc. | |||
| HSPA1A | HSPA1A HSP72; HSPA1; | 258 nt | TargetScan | 33 | miR-4699-3p; miR-4635; miR-127-5p; miR-527; miR-561; etc. |
| miRanda | 9 | miR-146a; miR-146b-5p; miR-183; miR-34c-5p; miR-449a; etc. | |||
| DIANA-MicroT-CDS | 8 | miR-146b-5p; miR-146a; miR-548ao-5p; miR-34a; miR-412; etc. | |||
| RegRNA | 62 | miR-127-5p; miR-146b-5p; miR-561; miR-570; miR-1264; etc. | |||
| HSPA6 | HSP70B' | 307 nt | TargetScan | 40 | miR-106a; miR-20a; miR-20b; miR-106b; miR-519d; etc. |
| miRanda | 23 | miR-376a; miR-20b; miR-17; miR-106a; miR-93; etc. | |||
| DIANA-MicroT-CDS | 10 | miR-4646-5p; miR-298; miR-5688; miR-20a; miR-106b; etc. | |||
| RegRNA | 70 | miR-103b; miR-106a; miR-298; miR-20b; miR-376a; etc | |||
| HSPC1 | HSP90; HSP90N; HSP90A; LAP2; HSPN; HSPCA; HSP90AA1 | 974 nt | TargetScan | 136 | miR-9; miR-361-5p; miR-495; miR-224; miR-370; etc. |
| miRanda | 14 | miR-96; miR-1271; miR-411; miR-148a; miR-377; etc. | |||
| DIANA-MicroT-CDS | 62 | miR-4778-3p; miR-578; miR-515-5p; miR-529e; miR-205-5p; etc. | |||
| RegRNA | 182 | miR-1224; miR-142-3p; miR-632; miR-3119; miR-518d-5p; etc. |
a3′UTR sequence of human genes was obtained through the UCSC genome browser
bAll searches were performed with default settings. Search results refer to the total number of putative miRNA regulatory sites listed following each search query
cTarget sites are defined by their cognate human miRNA. All miRNAs in bold were detected by at least one other search algorithm