Table 1.
Polymorphisms | N (%) | ||||||||
---|---|---|---|---|---|---|---|---|---|
Genotype | Allele | ||||||||
HSPA1A (rs1043618) | GG | GC | CC | χ 2 | p | G | C | χ 2 | p |
Patients | 94 (46.3) | 76 (37.4) | 33 (16.3) | 13.45 | <0.01 | 264 (65.0) | 142 (35.0) | 10.35 | <0.01 |
Control | 135 (55.5) | 94 (38.7) | 14 (5.8) | 364 (75.0) | 122 (25.0) | ||||
Male patients | 52 (46.0) | 42 (37.2) | 19 (16.8) | 6.17 | <0.05 | 146 (64.6) | 80 (35.4) | 5.42 | <0.05 |
Male controls | 83 (55.4) | 56 (37.3) | 11 (7.3) | 222 (74.0) | 78 (26.0) | ||||
Female patients | 42 (46.7) | 34 (37.8) | 14 (15.5) | 8.36 | <0.05 | 118 (65.6) | 62 (34.4) | 5.18 | <0.05 |
Female controls | 52 (55.9) | 38 (40.9) | 3 (3.2) | 142 (76.3) | 44 (23.7) | ||||
HSPA1B (rs1061581) | AA | AG | GG | χ 2 | p | A | G | χ 2 | p |
Patients | 84 (41.4) | 89 (43.8) | 30 (14.8.) | 0.01 | 0.9999 | 257 (63.3) | 149 (36.7) | 0.01 | 0.9999 |
Control | 100 (41.2) | 107 (44.0) | 36 (14.8) | 307 (63.2) | 179 (36.8) | ||||
Male patients | 47 (41.6) | 48 (42.5) | 18 (15.9) | 0.33 | 0.8479 | 142 (62.8) | 84 (37.2) | 0.07 | 0.7913 |
Male controls | 58 (38.7) | 69 (46.0) | 23 (15.3) | 185 (61.7) | 115 (38.3) | ||||
Female patients | 37 (41.1) | 41 (45.6) | 12 (13.3) | 0.42 | 0.8106 | 115 (63.9) | 65 (36.1) | 0.12 | 0.7290 |
Female controls | 42 (45.1) | 38 (40.9) | 13 (14.0) | 122 (65.6) | 64 (34.4) | ||||
HSPA1L (rs2227956) | TT | TC | CC | χ 2 | p | T | C | χ 2 | p |
Patients | 139 (68.5) | 59 (29.0) | 5 (2.5) | 0.53 | 0.7672 | 337 (83.0) | 69 (17.0) | 0.47 | 0.5214 |
Control | 174 (71.6) | 64 (26.3) | 5 (2.1) | 412 (84.8) | 74 (15.2) | ||||
Male patients | 76 (67.2) | 35 (31.0) | 2 (1.8) | – | 0.5327 | 187 (82.7) | 39 (17.3) | 0.84 | 0.3594 |
Male controls | 108 (72.0) | 41 (27.3) | 1 (0.7) | 257 (85.7) | 43 (14.3) | ||||
Female patients | 63 (70.0) | 24 (26.7) | 3 (3.3) | – | 0.9250 | 150 (83.3) | 30 (16.7) | 0 | 1 |
Female controls | 66 (71.0) | 23 (24.7) | 4 (4.3) | 155 (83.3) | 31 (16.7) |
All data in italics are statistically significant