Table 5.
Effect | Females | Males | Sex | Genotype | Sex × genotype | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GG | GC | CC | GG | GC | CC | F | p | F | p | F | p | ||
HSPA1A rs1043618 (+190G/C) | PANSS positive | 21.28 ± 5.54 | 23.29 ± 5.54 | 21.07 ± 4.61 | 23.02 ± 6.01 | 25.09 ± 5.38 | 22.31 ± 5.59 | 3.32 | 0.0699 | 3.58 | <0.05 | 0.03 | 0.9703 |
PANSS negative | 25.26 ± 6.37 | 26.06 ± 6.31 | 24.86 ± 6.04 | 26.58 ± 5.90 | 25.17 ± 6.14 | 27.63 ± 6.53 | 1.21 | 0.2727 | 0.12 | 0.8828 | 1.18 | 0.3101 | |
PANSS general | 43.48 ± 8.37 | 44.53 ± 7.41 | 41.50 ± 7.13 | 46.25 ± 8.67 | 45.83 ± 8.04 | 46.79 ± 8.46 | 5.96 | <0.05 | 0.18 | 0.8348 | 0.68 | 0.5085 | |
Age of onset (years) | 28.86 ± 6.50 | 27.20 ± 8.32 | 25.36 ± 6.98 | 23.29 ± 4.98 | 24.21 ± 5.56 | 26.74 ± 6.08 | 4.95 | <0.05 | 0.19 | 0.8268 | 4.23 | <0.05 | |
AA | AG | GG | AA | AG | GG | ||||||||
HSPA1B rs1061581 (+1267A/G) | PANSS positive | 21.38 ± 5.58 | 23.02 ± 5.45 | 20.50 ± 4.76 | 22.79 ± 5.93 | 24.91 ± 5.56 | 22.67 ± 5.54 | 4.11 | <0.05 | 3.28 | <0.05 | 0.06 | 0.9369 |
PANSS negative | 26.30 ± 6.87 | 25.32 ± 5.83 | 23.67 ± 5.61 | 26.85 ± 5.97 | 25.38 ± 6.53 | 26.89 ± 5.36 | 1.66 | 0.1995 | 0.98 | 0.3782 | 0.72 | 0.4885 | |
PANSS general | 44.40 ± 8.52 | 43.70 ± 7.45 | 40.50 ± 6.50 | 45.89 ± 8.78 | 46.17 ± 7.93 | 47.00 ± 8.62 | 7.07 | <0.01 | 0.32 | 0.7237 | 1.02 | 0.3622 | |
Age of onset (years) | 29.00 ± 6.38 | 27.15 ± 8.00 | 25.50 ± 7.55 | 23.53 ± 5.19 | 24.44 ± 6.14 | 25.39 ± 4.28 | 6.02 | <0.05 | 0.31 | 0.7344 | 2.81 | 0.0625 | |
TT | TC | CC | TT | TC | CC | ||||||||
HSPA1L rs2227956 (+2437T/C) | PANSS positive | 22.44 ± 5.57 | 21.25 ± 5.13 | 19.00 ± 5.29 | 23.81 ± 5.71 | 23.59 ± 6.01 | 19.00 ± 2.83 | 0.46 | 0.4969 | 1.45 | 0.2369 | 0.20 | 0.8214 |
PANSS negative | 26.17 ± 6.31 | 24.50 ± 5.87 | 19.33 ± 4.93 | 26.45 ± 6.18 | 25.68 ± 6.15 | 28.00 ± 4.24 | 2.89 | 0.0907 | 1.11 | 0.3313 | 1.13 | 0.3257 | |
PANSS general | 44.60 ± 7.66 | 41.54 ± 8.10 | 38.00 ± 3.60 | 46.68 ± 7.94 | 45.35 ± 9.37 | 41.50 ± 2.12 | 1.45 | 0.2306 | 2.46 | 0.0876 | 0.24 | 0.7897 | |
Age of onset (years) | 27.63 ± 7.74 | 27.75 ± 6.71 | 28.33 ± 4.16 | 24.65 ± 5.79 | 23.32 ± 4.82 | 22.50 ± 2.12 | 4.54 | <0.05 | 0.11 | 0.8939 | 0.48 | 0.6187 |
All data in italics are statistically significant
F Fisher–Snedecor test in multivariate analysis