Table 5.

The results of two-way ANOVA (sex and genotype distributions) for the PANSS subscales and age of onset of paranoid schizophrenia

	Effect	Females			Males			Sex		Genotype		Sex × genotype
		GG	GC	CC	GG	GC	CC	F	p	F	p	F	p
HSPA1A rs1043618 (+190G/C)	PANSS positive	21.28 ± 5.54	23.29 ± 5.54	21.07 ± 4.61	23.02 ± 6.01	25.09 ± 5.38	22.31 ± 5.59	3.32	0.0699	3.58	<0.05	0.03	0.9703
	PANSS negative	25.26 ± 6.37	26.06 ± 6.31	24.86 ± 6.04	26.58 ± 5.90	25.17 ± 6.14	27.63 ± 6.53	1.21	0.2727	0.12	0.8828	1.18	0.3101
	PANSS general	43.48 ± 8.37	44.53 ± 7.41	41.50 ± 7.13	46.25 ± 8.67	45.83 ± 8.04	46.79 ± 8.46	5.96	<0.05	0.18	0.8348	0.68	0.5085
	Age of onset (years)	28.86 ± 6.50	27.20 ± 8.32	25.36 ± 6.98	23.29 ± 4.98	24.21 ± 5.56	26.74 ± 6.08	4.95	<0.05	0.19	0.8268	4.23	<0.05
		AA	AG	GG	AA	AG	GG
HSPA1B rs1061581 (+1267A/G)	PANSS positive	21.38 ± 5.58	23.02 ± 5.45	20.50 ± 4.76	22.79 ± 5.93	24.91 ± 5.56	22.67 ± 5.54	4.11	<0.05	3.28	<0.05	0.06	0.9369
	PANSS negative	26.30 ± 6.87	25.32 ± 5.83	23.67 ± 5.61	26.85 ± 5.97	25.38 ± 6.53	26.89 ± 5.36	1.66	0.1995	0.98	0.3782	0.72	0.4885
	PANSS general	44.40 ± 8.52	43.70 ± 7.45	40.50 ± 6.50	45.89 ± 8.78	46.17 ± 7.93	47.00 ± 8.62	7.07	<0.01	0.32	0.7237	1.02	0.3622
	Age of onset (years)	29.00 ± 6.38	27.15 ± 8.00	25.50 ± 7.55	23.53 ± 5.19	24.44 ± 6.14	25.39 ± 4.28	6.02	<0.05	0.31	0.7344	2.81	0.0625
		TT	TC	CC	TT	TC	CC
HSPA1L rs2227956 (+2437T/C)	PANSS positive	22.44 ± 5.57	21.25 ± 5.13	19.00 ± 5.29	23.81 ± 5.71	23.59 ± 6.01	19.00 ± 2.83	0.46	0.4969	1.45	0.2369	0.20	0.8214
	PANSS negative	26.17 ± 6.31	24.50 ± 5.87	19.33 ± 4.93	26.45 ± 6.18	25.68 ± 6.15	28.00 ± 4.24	2.89	0.0907	1.11	0.3313	1.13	0.3257
	PANSS general	44.60 ± 7.66	41.54 ± 8.10	38.00 ± 3.60	46.68 ± 7.94	45.35 ± 9.37	41.50 ± 2.12	1.45	0.2306	2.46	0.0876	0.24	0.7897
	Age of onset (years)	27.63 ± 7.74	27.75 ± 6.71	28.33 ± 4.16	24.65 ± 5.79	23.32 ± 4.82	22.50 ± 2.12	4.54	<0.05	0.11	0.8939	0.48	0.6187

All data in italics are statistically significant

F Fisher–Snedecor test in multivariate analysis