Fig. 7.

Knockdown of KLF4 eliminates the EGCG-induced growth inhibition of NCI-N87 cells. siKLF4 indicates the KLF4 siRNA group; NS indicates the nonspecific siRNA group. a Western blot analysis revealed the successful knockdown of KLF4; b cells were transfected with KLF4 siRNA, followed by incubation with 50 μM EGCG for 48 h; MTT assay revealed that knockdown of KLF4 could reduce the slowed cell growth caused by treatment with EGCG (*p < 0.01 vs. NS group; #p < 0.01 vs. NS + EGCG group); c western blot analysis revealed that knockdown of KLF4 reversed the alternations of p21, cycin D, and CDK4 expression induced by EGCG (*p < 0.01 vs. NS group; #p < 0.01 vs. NS + (EGCG) group)