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. 2013 Aug 27;8(1):73–81. doi: 10.1007/s11693-013-9123-5

Table 3.

p-values for the significance of deviation of the mean of different metrics for the set of essential nodes vis-à-vis all nodes in a network

Organism p (degree) p (Betweenness centrality) p (Closeness centrality) p (Pairwise disconnectivity index)
Acinetobacter baylyi < 10−6 < 10−6 0.22 0.14
Arabidopsis thaliana 8.52 × 10−3 0.05 0.18 0.15
Bacillus subtilis < 10−6 < 10−6 0.89 0.40
Caenorhabditis elegans 8.40 × 10−5 0.25 0.10 0.01
Escherichia coli < 10−6 < 10−6 0.92 0.98
Francisella novicida < 10−6 < 10−6 0.50 0.49
Haemophilus influenzae < 10−6 0.26 0.22 0.36
Helicobacter pylori < 10−6 6.55 × 10−4 0.86 0.03
Mycobacterium tuberculosis < 10−6 < 10−6 0.20 0.07
Mycoplasma genitalium < 10−6 0.05 0.76 0.18
Mycoplasma pulmonis < 10−6 < 10−6 0.87 0.00
Pseudomonas aeruginosa < 10−6 < 10−6 0.14 0.05
Saccharomyces cerevisiae < 10−6 < 10−6 0.28 0.09
Salmonella enterica serovar typhi < 10−6 < 10−6 0.92 0.06
Salmonella typhimurium < 10−6 0.0163 0.85 0.15
Staphylococcus aureus NCTC < 10−6 < 10−6 0.24 0.18
Staphylococcus aureus subsp. aureus N315 < 10−6 < 10−6 0.96 0.05
Streptococcus pneumoniae 2 × 10−6 7.14 × 10−4 0.57 0.11
Streptococcus sanguinis < 10−6 < 10−6 0.61 < 10−6
Vibrio cholerae < 10−6 < 10−6 0.57 0.89

Poor p values (p > 0.01) have been shown in bold. The table clearly shows that metrics such as closeness centrality and pairwise disconnectivity index cannot be used to selectively delineate essential nodes