Table 1. Nested gene structures lost in clawed frog or chicken genomes.

Host gene	Nested gene	Explanation
ASTN2	TRIM32	nested absent in frog
CACNA2D3	LRTM1	both absent in frog
CASK	GPR82	nested absent in frog
CENPP	ECM2	host gene absent in frog
	ASPN	host gene absent in frog
	OMD	both absent in frog
	OGN	host gene absent in frog
CTNNA1	LRRTM2	nested absent in frog
CTNNA3	LRRTM3	host gene absent in frog
FBXL13	LRRC17	nested absent in frog
FYCO1	CXCR6	host absent in frog, nested absent in chicken
IMMP2L	LRRN3	host gene absent in frog
MED12L	P2RY13	host gene absent in frog
	P2RY12	host gene absent in frog
PC	LRFN4	both absent in chicken
RNF123	AMIGO3	nested absent in frog
SND1	LRRC4	host absent in chicken
SYN1	TIMP1	nested absent in frog
TFB1M	CLDN20	nested absent in frog

The table lists human protein-coding different strand nested gene structures that are also found in coelacanth and/or zebrafish but are absent in clawed frog (X. tropicalis) or chicken genomes. The genes were selected (as described in the Methods and Table S3) from a previously published list of human nested genes [12]. The missing host or nested genes are marked in bold. Nested genes that encode LRR-superfamily proteins are underlined.