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. 2014 Feb 24;9(2):e89917. doi: 10.1371/journal.pone.0089917

Table 1. ED50 values of antibiotics in the honeybee S. aureus infection model.

Antibiotics A. mellifera L. A. mellifera L. B. mori a B. mori a
i.c. p.o. i.h. p.o.
Tetracycline 0.2b 2 0.4 8
Vancomycin 0.02 >330 0.3 >400
Kanamycin 0.4 >330 3 >500

ED50 values of tetracycline, vancomycin, and kanamycin against S. aureus infection in in-hive worker bees (n = 5) were determined 24 h after infection. Antibiotics were injected into the cavities (i.c.) or orally administered (p.o.), and live bacterial suspension of S. aureus was injected immediately after antibiotic treatment.

a

ED50 values of B. mori were previously reported [16].

b

µg/insect.