Figure 1.

Brain regions with increased/decreased amplitude of low-frequency fluctuation (ALFF) in pediatric bipolar disorder patients are superimposed on a T1 template.

Notes: The ALFF showed a decrease (cold colors) in the left precuneus (d), left superior parietal lobule (e), and bilateral inferior occipital gyrus (c1 and c2), and an increase (hot colors) in bilateral caudate (b1 and b2) and left pallidum (a). The voxels with P=0.001 and a cluster size of 6 were used to identify the clusters with significant differences between the pediatric bipolar disorder and healthy control groups (P<0.05, corrected). Patients versus controls; two-sample t-test; P<0.05, corrected.

Abbreviations: L, left; R, Right.