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. 2014 Feb 18;7:305–314. doi: 10.2147/OTT.S57126

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© 2014 Shen et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Ulinastatin (UTI) and curcumin (CUR) inhibits liver metastasis and prolongs survival. (A) Luciferase-expressing HCT-116 cells were injected into the spleens of BLAB/c mice. The control group (n=7) received vehicle, the UTI group (n=7) was injected with UTI at 8,000 U/mouse once daily, the CUR group (n=7) was administered orally CUR alone (1 g/kg) once daily, and the UTI plus CUR group (n=7) was treated with a combination of UTI (8,000 U/mouse) and CUR (1 g/kg). Therapy was continued for 4 weeks. Bioluminescence imaging was used to monitor liver metastasis of HCT-116-Luc-GFP cells in vivo 1 day and 28 days after splenic injection. (B) Survival of mice treated with/without UTI and/or CUR was assayed after injecting HCT-116-Luc-GFP cells.