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. 2014 Feb 25;5:80. doi: 10.3389/fphys.2014.00080

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Copyright © 2014 Retamal.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summary of the effect of ROS/RNS over Cxs hemichannels. A cellular stress (i.e., metabolic inhibition) induces an increase of ROS/RNS production, which in turn, can affect directly Cx hemichannels (as observed in Cys271 of Cx43). This molecular modification can induce and increase in the open probability of hemichannels and/or changes in their permeability to large molecules. Additionally, the posttranslational modification induced by ROS/RNS can also lead to an increase of the permeability of nitro oxide and possibly of other free radicals as well.