Table 1.
List of all Cxs and Panx hemichannels that are known to be affected by changes of cellular redox potential.
| Connexin/Pannexin | Molecule/Condition | Experimental model | Amino acid modified | Effect | Ref |
|---|---|---|---|---|---|
| Cx32 | NO donor | Fleta | Decrease hemichannel opening | Figueroa et al., 2013 | |
| Cx37 | NO donor | Hela | Increase hemichannel opening | Figueroa et al., 2013 | |
| Cx40 | NO donor | Hela | Increase hemichannel opening | Figueroa et al., 2013 | |
| Cx43 | Metabolic Inhibition! | Astrocytes | Increase hemichannel opening | Contreras et al., 2002 | |
| NO donor | |||||
| NO donor | Astrocytes | Increase hemichannel opening | Retamal et al., 2006 | ||
| DTT | HeLa | Increase hemichannel opening | Retamal et al., 2007b | ||
| Inflammation like condition | Astrocytes | Increase hemichannel opening | Retamal et al., 2007b | ||
| NO donor | Endothelial Cells | C271-S-nitrosylation | Decrease IP3 permeability of GJCs | Straub et al., 2011 | |
| smoking-induced cell Injury | N2A | Increase hemichannel opening | Ramachandran et al., 2007 | ||
| Cadmium-induced oxidative str.e. | Fibroblast | Increase hemichannel opening | Fang et al., 2011 | ||
| Cx46 | NO donor | Xenopus Oocyte | Modify VoItaje sensitivity and opening-closing kinetics | Retamal et al., 2009 | |
| Panxl | Ischemic-like conditions | Neurons | Increase hemichannel opening | Thompson et al., 2006 | |
| Ischemic-like conditions | Neurons | Increase hemichannel opening | Zhang et al., 2008 | ||
| TCEP | N2A | Decrease hemichannel opening | Bunse et al., 2009 | ||
| NO donor | HEK293T | Cys 40 and 346—S-nuosyla:lon | Decrease hemichannel opening | Lohman et al., 2012 |
This table specifies the model in which the experiments were performed, the observed effects on hemichannel activity and which Cys group was modified.