Table 1.
L. monocytogenes mutants that differentially activate IFN-β.
| Insertion site | L. m. EGDe gene identifier | Description | Pathway |
|---|---|---|---|
| (A) L. monocytogenes MUTANTS THAT INDUCE LOW LEVELS OF IFN-β | |||
| LMRG_02622.6 | lmo0200 | prfA, main virulence regulator of L. monocytogenes | Virulence |
| LMRG_02624 | lmo0202 | hly, encoding Listeriolysin O toxin | Virulence |
| LMRG_00367.6 | lmo0679 | Similar to flagellar biosynthetic protein flhB | Mobility and chemotaxis |
| LMRG_00380.6 | lmo0692 | Two-component sensor histidine kinase CheA | Sensor/signal transduction |
| LMRG_00386.2 | lmo0697 | Similar to flagellar hook protein FlgE | Mobility and chemotaxis |
| LMRG_00394 | lmo0705 | Similar to flagellar hook-associated protein FlgK | Mobility and chemotaxis |
| LMRG_00397.6 | lmo0708 | Similar to hypothetical flagellar protein | Mobility and chemotaxis |
| LMRG_00402.2 | lmo0713 | Flagellar basal-body M-ring protein fliF | Mobility and chemotaxis |
| LMRG_02761.6 | lmo1687 | N/A | Unknown |
| LMRG_02767.6 | lmo1693 | N/A | Unknown |
| LMRG_01002.6 | lmo1855 | D-alanyl-D-alanine carboxipeptidase | Cell wall |
| LMRG_01003.6 | lmo1856 | Purine nucleoside phosphorylase | Nucleotide metabolism |
| (B) L. monocytogenes MUTANTS THAT INDUCE HIGH LEVELS OF IFN-β | |||
| LMRG_00151.6 | lmo2750 | Similar to para-aminobenzoate synthase component I | Amino acids metabolism |
| LMRG_00277.6 | lmo0595 | Similar to O-acetylhomoserine sulfhydrylase | Amino acids metabolism |
| LMRG_00310.2 | lmo0644 | Membrane sulfatase family protein | LTA |
| LMRG_00332.2 | lmo2469 | Similar to amino acid transporter/amino acid permease family protein | Transporters |
| LMRG_00541.6 | lmo1079 | Similar to YfhO | Unknown |
| LMRG_00672.6 | lmo1226 | Similar to transporter (B. subtilis YdgH); lmo1225 is a transcriptional regulator from marR family | Transporters |
| LMRG_00860.2 | lmo1408 | ladR, a transcriptional repressor for mdrL | Regulation |
| LMRG_01641.6 | lmo2191 (~180 upstream) | Aresnate reductase, transcriptional regulator spx family | Regulation |
| LMRG_01692.6 | lmo2555 | Glycosyl transferase | LTA |
| LMRG_01693.6 | lmo2554 | Galactosyl transferase | LTA |
| LMRG_01775.6 | lmo2473 | N/A | unknown |
| LMRG_01983.6 | lmo2713 | Cell wall bound protein, contains 1 GW-repeat | Cell surface proteins |
| LMRG_02415.6 | lmo0170 | Hypothetical protein | Unknown |
| LMRG_02642.6 | lmo0220 | Highly similar to cell division protein ftsH | Cell division |
| LMRG_02673.6 | lmo0233 | Similar to DNA repair protein radA/sms from E. coli | DNA repair |
| LMRG_00225.6/02811.6 | lmo1786 (~500 bp upstream) | Insertion is a 100 bp upstream of an undefined 36 aa ORF | Unknown |