Table 4.
Univariate and multivariate associations between demographic, clinical and neuropsychological characteristics and progression to dementia (CDR≥1) over the 4-year follow-up period.
Univariate models | Multivariate model | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Baseline Characteristics | Variables | β | p | OR | 95% CI | AICC | β | p | OR | 95% CI | ||
low | upper | low | upper | |||||||||
Demographics | Age | .091 | .005 | 1.094 | 1.028 | 1.166 | 202.535 | .095 | .017 | 1.100 | 1.017 | 1.190 |
Everyday functioning measures |
ADCS-ADL- PI | .193 | <.001 | 1.212 | 1.115 | 1.318 | 181.617 | .000 | .999 | 1.000 | 0.835 | 1.198 |
IQCODE | 2.925 | <.001 | 19.990 | 8.056 | 49.603 | 151.226 | 2.179 | .017 | 8.838 | 1.475 | 52.935 | |
DEX | .037 | .005 | 1.038 | 1.011 | 1.065 | 179.785 | .027 | .307 | 1.027 | 0.976 | 1.081 | |
Screening battery | BNT | −.085 | .027 | 0.919 | 0.853 | 0.990 | 201.451 | −.031 | .628 | 0.969 | 0.853 | 1.100 |
MMSE | −.435 | <.001 | 0.647 | 0.563 | 0.743 | 171.131 | −.330 | .054 | 0.719 | 0.514 | 1.006 | |
Animals and Vegetables | −.118 | <.001 | 0.889 | 0.838 | 0.943 | 180.048 | −.038 | .442 | 0.963 | 0.876 | 1.059 | |
Clock Drawing Test | −.418 | <.001 | 0.659 | 0.546 | 0.794 | 187.717 | −.263 | .137 | 0.769 | 0.543 | 1.087 | |
Executive cognition measures |
D-KEFS Stroop Test | −.144 | <.001 | 0.866 | 0.803 | 0.934 | 187.104 | .037 | .573 | 1.038 | 0.911 | 1.183 |
Verbal Concept Attainment Test | −.175 | <.001 | 0.840 | 0.766 | 0.920 | 180.821 | −.030 | .691 | 0.970 | 0.835 | 1.127 | |
Stanford Binet Absurdities Test | −.159 | <.001 | 0.853 | 0.782 | 0.929 | 184.345 | −.002 | .978 | 0.998 | 0.849 | 1.173 | |
Brief Test of Attention | −.130 | <.001 | 0.878 | 0.815 | 0.945 | 182.909 | .032 | .638 | 1.033 | 0.902 | 1.183 | |
Hayling Test | −.382 | <.001 | 0.682 | 0.552 | 0.844 | 180.813 | −.316 | .069 | 0.729 | 0.519 | 1.026 | |
Porteus Maze Test | −.131 | .012 | 0.877 | 0.792 | 0.972 | 188.420 | .013 | .889 | 1.013 | 0.843 | 1.218 | |
Alternate Uses Test | −.131 | <.001 | 0.878 | 0.818 | 0.942 | 181.617 | −.031 | .629 | 0.969 | 0.854 | 1.100 | |
Corrections and Completions test | −.173 | .017 | 0.841 | 0.730 | 0.969 | 188.965 | .103 | .331 | 1.108 | 0.901 | 1.363 |