Table 1. Characteristics of the 14 studies included in the meta-analysis.
Author/Year | Country | Disease | Study design | Reference method | QUADAS score | Total nnumber | Specimen Source | DNA Extraction kit | Instrument | Dye | Final volume(μL) |
---|---|---|---|---|---|---|---|---|---|---|---|
Willmore-Payne 200517 | USA | melanoma | CS | SEQ | 12 | 90 | PE | NA | HR-1 | LCGreen | 10 |
Simi 200814 | Italy | CRCs | CS | SEQ | 9 | 116 | FF | Qiagen | RG 6000 | Syto 9 | 10 |
Pichler 200913 | Austria | CRCs | CS | SEQ | 10 | 13 | FFPE | Qiagen | LC 480 | HRMM | 20 |
Seth 200918 | UK | CRCs | CS | SEQ | 9 | 29 | FFPE | Qiagen | HR-1 | Syto 9 | 10 |
Bennani 201019 | Morocco | CRCs | CS | SEQ | 10 | 62 | PE | Qiagen | LC 480 | NA | 10 |
Borras 201120 | Spain | CRCs/LCs | CS | SEQ | 9 | 54 | FFPE | Qiagen | LC 480 | HRMM | 10 |
Bozzao 201221 | Italy | CRCs | CS | SEQ | 8 | 117 | PE | Qiagen | RG 6000 | Syto 9 | NA |
Hsieh 201222 | China | CRCs | CS | SEQ | 11 | 182 | FFPE | Qiagen | LC 480 | HRMM | 10 |
Krol 201223 | Netherlands | CRCs | CS | SEQ | 11 | 126 | FF | Qiagen | LC 480 | HRMM | 25 |
Mancini 201224 | Italy | TNs | CS | SEQ | 11 | 17 | FF | Qiagen | RG 6000 | Syto 9 | 20 |
Ney 201225 | Germany | Mixed | CS | SEQ | 11 | 194 | FFPE | Qiagen | LC 480 | HRMM | 20 |
Yang 201226 | Germany | melanoma | CS | SEQ | 13 | 31 | FFPE | Qiagen | RGQ | EvaGreen | 20 |
Guedes 201327 | Portugal | CRCs | CS | SEQ | 8 | 201 | FFPE | Qiagen | LC 480 | HRMM | 10 |
Richter 201328 | Australia | melanoma | CS | SEQ | 13 | 92 | FFPE | NA | LC 480 | Syto 9 | 10 |
CRCs, colorectal cancers; LCs: lung cancers; TNs, thyroid nodules; Mixed, colorectal cancers, endometrial cancers, melanomas, gastrointestinal stromal tumors; CS, Cross-sectiona; SEQ, DNA sequencing; PE, paraffin-embedded; FF, fresh frozen tissue; FFPE, formalin-fixed paraffin-embedded; NA, not available; LC 480, LightCycler 480; RG 6000, RotorGene 6000; RGQ, Rotor-Gene Q; HRMM, LightCycler LC480 High Resolution Melting Master.