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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Transl Stroke Res. 2014 Jan 5;5(1):59–68. doi: 10.1007/s12975-013-0319-5

Figure 1. ASIC1a as a target for stroke translational research.

Figure 1

Neuron with enlargement of soma displaying ASICs. When ASICs are activated by protons they conduct sodium and calcium into the cell. Activation of ASICs contributes to neuronal injury by increasing the intracellular concentration of calcium. In the presence of these inhibitors ASIC activity is diminished, attenuating ASIC mediated neurotoxicity. Amiloride is a non- specific inhibitor of ASIC subunits and other ion channels. NSAIDs are non-specific drugs, however Ibuprofen and Flurbiprofen are also inhibitors of ASIC. Please see section “ASIC Inhibitors”.