Fig. 5.
IL-1 family members in the differentiation and function of innate and adaptive lymphoid cells. “+” above arrows refers to stimulation of target cells by IL-1 family members with or without other cytokines (IL-12, IL-25, thymic stromal lymphopoietin (TSLP), IL-23). Arrows point to products of stimulated cells and cellular effectors (on the right part). ncTh1, non-conventional Th1 cells (human). The → → sign for the Th17 cells and Tγδ17 cells indicates the presence of intermediate cells (endothelium, epithelium) which respond to IL-17.