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. Author manuscript; available in PMC: 2014 Feb 25.
Published in final edited form as: Oncol Rep. 2008 Jul;20(1):203–210.

Figure 1.

Figure 1

(A) The RB1 domain structure indicating conserved regions (A and B domains), cyclin/cdk docking site (black box) and the location of missense variants found in tumor samples. (B) The LGI1 domain structure indicating signal peptide (SP), cysteine-rich domains (CC) and the leucine-rich repeat (LRR). Mutations found mutated in the germline in epilepsy patients are shown at the bottom of the diagram. Mutations found in tumor samples (this study) are shown at the top of the diagram. The scissors show the cleavage site.