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. Author manuscript; available in PMC: 2014 Feb 25.
Published in final edited form as: Oncol Rep. 2008 Jul;20(1):203–210.

Table I.

Somatic mutations in brain cancer.

IDa Race/ethnicity Type of tumorb Gene Exon Genomicc Predicted RNAd Predicted protein
72 Caucasian 9450 - Oligodendroglioma, NOS, LGG TP53 6 12713G>T 895G>T S215I
73 Caucasian 9451 - Oligodendroglioma, anaplastic, HGG RB1 4 41314A>T 555A>T K130Il
4 41329T>C 570T>C L135P
13 73189G>A 1427G>A D421N
17 77503C>T 1695C>T T510I
18 49221G>A 1862G>A D566N
LGI1 4 19643A>G 601A>G N125S
4 19697T>G 655T>G L144S
8 39800A>G 1815A>G N531D
78 Caucasian 9400 - Astrocytoma, NOS, HGG RB1 2 3624A>G 422A>G G86R
10 63759A>G 1145A>G K327E
12 69672A>G 1335A>G N390S
16 76409C>A 1606C>A N480K
20 155992A>G 2201A>G I679V
LGI1 4 19631T>A 589T>A I122K
6 34942A>G 847A>G K207R
6 34987T>C 892T>C I223T
8 39810A>T 1825A>T N534I
110 Caucasian 9440 - GBM, HGG TP53 9 13797C>T 1068C>T R273C
118 Caucasian 9440 - GBM, HGG LGI1 4 19694A>G 652A>G H143R
127 Caucasian 9400 - Astrocytoma, NOS, HGG TP53 5 12524A>G 787A>G H179R
189 Caucasian 9440 - GBM, HGG TP53 5 12469G>A 732G>A A161T
193 Caucasian 9440 - GBM, HGG RB1 4 41322A>C 563A>C N133H
13 73164A>C 1402A>C K412N
21 152566T>C 2115T>C F650S
LGI1 4 19648A>G 606A>G K128E
LGI1 6 34982C>G 887C>G C221W
8 39671C>T 1686C>T Q488X
8 39227A>G 1242A>G I340V
194 African American 9440 - Astrocytoma, GBM, HGG RB1 13 73214A>G 1452A>G K429R
205 African American 9401 - Anaplastic, HGG TP53 5 12524A>G 787A>G H179R
18 149243T>C 1884T>C I573T
RB1 20 156037C>G 2246C>G L694V
20 156032A>G 2241A>G Y692C
24 169609G>A 2675G>A E837K
25 173022C>T 2778C>T P871L
215 African American 9440 - GBM, HGG RB1 19 152574A>G 2123A>G K652E
LGI1 4 19694A>G 652A>G H143R
a

Patient identity.

b

ICD-O code with the associated name and further classified into LGG, low-grade glioma; HGG, high-grade glioma.

c

Nucleotide numbering according to the reference assembly: NC_000017 for TP53, NC_000013 for RB1 and NC_000010.9 for LGI1.

d

Numbering according to the NCBI RefSeq: NM_000546 for TP53, NM_000321 for RB1 and NM_005097 for LGI1.