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. Author manuscript; available in PMC: 2014 Feb 25.
Published in final edited form as: Oncol Rep. 2008 Jul;20(1):203–210.

Table II. Predicted functional consequence of somatic mutations in TP53.

IDa Predicted protein Reported inb Notes
189 A161T 70 tumors Part of the sequence-specific DNA-binding domain but not in any particular defined motif.
127
205		 H179R 135 tumors Part of motif III in the sequence-specific DNA-binding domain.
72 S215I 21 tumors Part of the sequence-specific DNA-binding domain but not in any particular defined motif.
110 R273C 581 tumors
9 LF families		 Part of motif IV in the sequence-specific DNA-binding domain. This residue directly contacts DNA, and is one of the most frequently mutated in p53.
a

Patient identity.

b

Number of times it has been found as a somatic or germline mutation (LF, Li-Fraumeni syndrome) and deposited at the IARC p53 mutation database (http://www-p53.iarc.fr/).