Skip to main content
NCBI home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1983 Jan;80(2):462–466. doi: 10.1073/pnas.80.2.462

Induction of leukemia by both fractionated x-irradiation and radiation leukemia virus involves loci in the chromosome 2 segment H-30-A.

D Meruelo, M Offer, A Rossomando
PMCID: PMC393398  PMID: 6300845

Abstract

A common link between the induction of leukemia by (i) fractionated doses of x-irradiation and (ii) radiation leukemia virus in mice may be established by the observation that the segment of chromosome 2 between the loci for the minor histocompatibility antigen H-30 and color coat agouti (H-30-A) includes distinct loci involved in susceptibility to leukemogenesis induced by factors i and ii.

Full text

PDF
462

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bailey D. W. Recombinant-inbred strains. An aid to finding identity, linkage, and function of histocompatibility and other genes. Transplantation. 1971 Mar;11(3):325–327. doi: 10.1097/00007890-197103000-00013. [DOI] [PubMed] [Google Scholar]
  2. Chattopadhyay S. K., Cloyd M. W., Linemeyer D. L., Lander M. R., Rands E., Lowy D. R. Cellular origin and role of mink cell focus-forming viruses in murine thymic lymphomas. Nature. 1982 Jan 7;295(5844):25–31. doi: 10.1038/295025a0. [DOI] [PubMed] [Google Scholar]
  3. Declève A., Lieberman M., Ihle J. N., Kaplan H. S. Biological and serological characterization of radiation leukemia virus. Proc Natl Acad Sci U S A. 1976 Dec;73(12):4675–4679. doi: 10.1073/pnas.73.12.4675. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Declève A., Lieberman M., Ihle J. N., Rosenthal P. N., Lung M. L., Kaplan H. S. Physicochemical, biological and serological properties of a leukemogenic virus isolated from cultured RadLV-induced lymphomas of C57BL/Ka mice. Virology. 1978 Oct 1;90(1):23–35. doi: 10.1016/0042-6822(78)90329-x. [DOI] [PubMed] [Google Scholar]
  5. Ellis R. W., Stockert E., Fleissner E. Association of endogenous retroviruses with radiation-induced leukemias of BALB/c mice. J Virol. 1980 Feb;33(2):652–660. doi: 10.1128/jvi.33.2.652-660.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. GROSS L. Attempt to recover filterable agent from x-ray induced leukemia. Acta Haematol. 1958 Jun;19(6):353–361. doi: 10.1159/000205455. [DOI] [PubMed] [Google Scholar]
  7. Haran-Chera N., Peled A. Thymus and bone marrow derived lymphatic leukaemia in mice. Nature. 1973 Feb 9;241(5389):396–398. doi: 10.1038/241396a0. [DOI] [PubMed] [Google Scholar]
  8. Ihle J. N. Experimental models and conceptual approaches to studies of lymphomas and leukemia: etiology, biology, and control. Semin Hematol. 1978 Apr;15(2):95–115. [PubMed] [Google Scholar]
  9. Ihle J. N., Joseph D. R., Pazmino N. H. Radiation leukemia in C57BL/6 mice. II. Lack of ecotropic virus expression in the majority of lymphomas. J Exp Med. 1976 Dec 1;144(6):1406–1423. doi: 10.1084/jem.144.6.1406. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Ihle J. N., McEwan R., Bengali K. Radiation leukemia in C57BL/6 mice. I. Lack of serological evidence for the role of endogenous ecotropic viruses in pathogenesis. J Exp Med. 1976 Dec 1;144(6):1391–1405. doi: 10.1084/jem.144.6.1391. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. KAPLAN H. S., BROWN M. B. A quantitative dose-response study of lymphoid-tumor development in irradiated C 57 black mice. J Natl Cancer Inst. 1952 Aug;13(1):185–208. [PubMed] [Google Scholar]
  12. KAPLAN H. S., BROWN M. B. Development of lymphoid tumors in nonirradiated thymic grafts in thymectomized irradiated mice. Science. 1954 Apr 2;119(3092):439–440. doi: 10.1126/science.119.3092.439. [DOI] [PubMed] [Google Scholar]
  13. KAPLAN H. S., BROWN M. B., HIRSCH B. B., CARNES W. H. Indirect induction of lymphomas in irradiated mice. II. Factor of irradiation of the host. Cancer Res. 1956 Jun;16(5):426–428. [PubMed] [Google Scholar]
  14. Kaplan H. S. On the natural history of the murine leukemias: presidential address. Cancer Res. 1967 Aug;27(8):1325–1340. [PubMed] [Google Scholar]
  15. LIEBERMAN M., KAPLAN H. S. Leukemogenic activity of filtrates from radiation-induced lymphoid tumors of mice. Science. 1959 Aug 14;130(3372):387–388. doi: 10.1126/science.130.3372.387. [DOI] [PubMed] [Google Scholar]
  16. Lieberman M., Declève A., Ihle J. N., Kaplan H. S. Rescue of a thymotropic, leukemogenic C-type virus from cultured, nonproducer-lymphoma cells of strain C57BL/Ka mice. Virology. 1979 Aug;97(1):12–21. doi: 10.1016/0042-6822(79)90368-4. [DOI] [PubMed] [Google Scholar]
  17. Mayer A., Dorsch-Häsler K. Endogenous MuLV infection does not contribute to onset of radiation- or carcinogen-induced murine thymoma. Nature. 1982 Jan 21;295(5846):253–255. [PubMed] [Google Scholar]
  18. Meruelo D., Nimelstein S. H., Jones P. P., Lieberman M., McDevitt H. O. Increased synthesis and expression of H-2 antigens on thymocytes as a result of radiation leukemia virus infection: a possible mechanism for H-2 linked control of virus-induced neoplasia. J Exp Med. 1978 Feb 1;147(2):470–487. doi: 10.1084/jem.147.2.470. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Meruelo D., Offer M., Flieger N. Genetics of susceptibility for radiation-induced leukemia. Mapping of genes involved to chromosomes 1, 2, and 4, and implications for a viral etiology in the disease. J Exp Med. 1981 Oct 1;154(4):1201–1211. doi: 10.1084/jem.154.4.1201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Meruelo D., Offer M., Rossomando A. Evidence for a major cluster of lymphocyte differentiation antigens on murine chromosome 2. Proc Natl Acad Sci U S A. 1982 Dec;79(23):7460–7464. doi: 10.1073/pnas.79.23.7460. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Meruelo D., Paolino A., Flieger N., Dworkin J., Offer M., Hirayama N., Ovary Z. Functional properties of Ly 11.2 lymphocytes: a role for these cells in leukemia? J Immunol. 1980 Dec;125(6):2719–2726. [PubMed] [Google Scholar]
  22. Pazmiño N. H., McEwan R., Ihle J. N. Radiation leukemia in C57BL/6 mice. III. Correlation of altered expression of terminal deoxynucleotidyl transferase to induction of leukemia. J Exp Med. 1978 Nov 1;148(5):1338–1350. doi: 10.1084/jem.148.5.1338. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Sankar-Mistry P., Jolicoeur P. Frequent isolation of ecotropic murine leukemia virus after x-ray irradiation of C57BL/6 mice and establishment of producer lymphoid cell lines from radiation-induced lymphomas. J Virol. 1980 Jul;35(1):270–275. doi: 10.1128/jvi.35.1.270-275.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES