Table 4.

Treatment-related adverse events

Treatment-related adverse events	Patients n (%)
	All grades	Grades 3–4
total	25 (50%)	4 (8%)
rash	10 (20%)	0
pruritus	4 (8%)	0
vitiligo	2 (4%)	0
asthenia	5 (10%)	0
diarrhea	6 (12%)	2 (4%)
hypophysitis	1 (2%)	1 (2%)
hepatitis	1 (2%)	1 (2%)
hypothyroidism	1 (2%)	0
hyperthyroidism	1 (2%)	1 (2%)
ALT/AST elevation	0	1 (2%)

ALT – alanine aminotransferase, AST – asparagine aminotransferase