Table 3.
Comparison of the different sectors around the optic disk regarding the retinal nerve fiber layer thickness (RNFLT) in the eyes of AD patients.
| Patient | MMSE | Clinical dementia rating | Disease duration (months) | Cup-to-disk ratio (left eye first) | SD-OCT calculations |
Age- and sex-matched calculations |
||
|---|---|---|---|---|---|---|---|---|
| Left eye | Right eye | Left eye | Right eye | |||||
| 1 | 17 | 2 | 3.2 | 0.40, 0.43 | 0 | 0 | 2 Atrophic | 2 Atrophic |
| 2 | 27 | 1 | 2.6 | 0,41, 0.38 | 0 | 0 | 1 Atrophic | 1 Atrophic |
| 3 | 20 | 2 | 6.9 | 0.40, 0.38 | 0 | 0 | 1 Atrophic | 1 Atrophic |
| 4 | 23 | 1 | 3 | 0.44, – | 0 | 0 | 2 Atrophic | – |
| 5 | 25 | 0.5 | 4 | 0.44, 0.45 | 0 | – | 0 | 0 |
| 6 | 23 | 1 | 7.4 | 0.43, 0.40 | 0 | 0 | 1 Atrophic | 1 Atrophic |
| 7 | 25 | 1 | 11 | 0.38, 0.35 | 0 | 0 | 0 | 0 |
| 8 | 29 | 0.5 | 6.3 | 0.44, 0.41 | 0 | 0 | 3 Atrophic | 4 Atrophic |
| 9 | 19 | 2 | 1.2 | 0.35, 0.29 | 0 | 0 | 2 Atrophic | 1 Atrophic |
| 10 | 20 | 2 | 18.3 | 0.33, 0.28 | 0 | 0 | 2 Atrophic | 3 Atrophic |
| 11 | 27 | 0.5 | 8.7 | 0.40, 0.40 | 0 | 0 | 0 | 4 Atrophic |
| 12 | 30 | 0,5 | 32 | –, 0.35 | – | 0 | – | 0 |
| 13 | 25 | 0.5 | 32.2 | 0.33, 0.40 | 0 | 1 Swollen | 1 Atrophic | 1 Atrophic |
| 14 | 29 | 0.5 | 22.5 | 0.35, 0.35 | 0 | 0 | 1 Atrophic | 2 Atrophic |
| 15 | 28 | 0.5 | 6.5 | 0.33, 0.31 | 0 | 1 Atrophic | 3 Atrophic | 2 Atrophic |
| 16 | 29 | 0.5 | 24.5 | 0.35, 0.35 | 0 | 0 | 0 | 0 |
| 17 | 21 | 1 | 8.5 | 0.45, 0.45 | 0 | 0 | 2 Atrophic | 1 Atrophic |
| 18 | 21 | 1 | 8.0 | 0.44, 0.44 | 4 Atrophic | 0 | 4 Atrophic | 0 |
| 19 | 14 | 2 | 6.6 | 0.37, 0.42 | 0 | 0 | 4 Atrophic | 2 Atrophic |
| 20 | 21 | 2 | 7.3 | 0.38, 0.33 | 0 | 0 | 0 | 3 Atrophic |
| 21 | 13 | 2 | 63.3 | 0.35, 0.41 | 0 | 0 | 3 Atrophic | 5 Atrophic |
| 22 | 11 | 2 | 7.9 | 0.33, 0.40 | 0 | 0 | 1 Atrophic | 1 Atrophic |
| Abnormal eyes | 1 | 2 | 16 | 16 | ||||
| Abnormal sectors | 4 | 2 | 33 | 34 | ||||
The first column shows the patient number, the second displays the reached points of the MMSE, the third column the Clinical Dementia Rating score, the fourth the months since diagnosis and the fifth the cup-to-disk ratio. The two blocks following show the data as obtained from the SD-OCT-based internal database (this is plotted for left and right eye). This was put into contrast to our calculations using age- and sex-matched controls (the two following blocks). At the bottom of this table, the count of the pathologic peripapillary sectors as well as eyes is shown. Thus the SD-OCT’s internal database was not able to detect 61 abnormal sectors and 29 eyes with pathologic RNFLT compared to our age- and sex-matched based model.