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Effect of central administration of KOR antagonist on pulsatile LH release in OVX rats without E2 treatment. Profiles of LH release in representative OVX rats treated with nor-BNI or vehicle (arrows) (A). Arrowheads indicate the peaks of LH pulses. Mean plasma LH concentrations and frequency, amplitude and baseline levels of LH pulses in OVX rats (B). The numbers in each column represent the numbers of animals used in each group. See Fig. 1 for details.
