Skip to main content
. 2014 Feb 17;124(3):1098–1113. doi: 10.1172/JCI69778

Figure 10. Treatment with calpain inhibitor reduces talin1 cleavage and glomerular injury following NTS treatment.

Figure 10

(A) NTS injection in mice reduces calpastatin expression in podocytes. (B) Glomerulus isolated at day 7 following NTS-injected mice treatment with calpain inhibitor (CI) reduces calpain activity. (C) Talin1 cleavage is prevented in NTS-injected mice treated with calpain inhibitor at day 7 after treatment. (D) Quantification of talin1 cleavage in C. (E) Albuminuria is reduced in mice treated with calpain inhibitor at day 7 following NTS injection. (F) Transmission electron micrographs illustrating reduced foot process effacement at 7 days in mice treated with calpain inhibitor following NTS injection. Scale bar: 1 μm. (G) Quantification of F. (H). Urine isolated from Pod-Tln1–KO mice exhibits increased calpain activity. n = 4 experiments. (I) Glomeruli isolated from Pod-Tln1–KO mice exhibit increased calpain activity. n = 4 experiments. (J) Albuminuria is not reduced in Pod-Tln1–KO mice following treatment with calpain inhibitor for 3 weeks. n = 4 mice. *P < 0.05.