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. 2014 Feb 17;124(3):1098–1113. doi: 10.1172/JCI69778

Figure 3. Podocyte-specific loss of talin1 results in glomerular capillary loop dilation with progressive glomerulosclerosis (scarring and fibrosis of the glomerulus) and interstitial fibrosis.

Figure 3

(A) Representative light microscopy images (H&E, PAS, and trichrome) of glomeruli from Pod-Tln1–KO mice revealing histological evidence of dilated glomerular capillary loops at 2 weeks of age (arrowheads), which progresses to diffuse glomerulosclerosis by 8 weeks. Scale bar: 25 μm. (B) Quantification as percentage of glomeruli, with capillary loop dilation at 2 weeks of age, in Pod-Tln1–KO mouse kidney sections when compared with control. n = 3 mice. (C) Quantification of glomerulosclerosis at 2, 4, and 8 weeks of age. n = 4 mice (D) Proteinaceous casts (arrowhead), dilated tubules, and severe interstitial fibrosis are observed in Pod-Tln1–KO mice at 8 weeks of age. Scale bar: 50 μm. (E) Quantification of interstitial fibrosis at 2, 4, and 8 weeks of age. n = 4 mice. *P < 0.001.